Disable and Delete                                         
thumbs.db file from Folders

Thumbs.db is is a cache file of the current thumb picture in that directory. To remove it, go for following steps:
1. Open Any Folder
2. Go to Tools Menu
3. Click On Folder Options
4. Go to “View” tab
5. In the section “Files And Folders” Click on “DO NOT CACHE THUMBNAILS”